Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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6,016 – 6,030 of 60,541 results

6,016

Cayman Chemical GCN2-IN-1, Purity: ≥90%, CAS: 1448693-69-3, 25 mg

An inhibitor of GCN2 (IC50 = ~0.2 µM for autophosphorylation); inhibits integrase phosphorylation (IC50 = ~0.2 µM for the HIV-1 enzyme); inhibits ELAV-like protein 1 protein dimerization (IC50 = 4.5 µM); decreases the viability in U251, XD456, U87, and LN-229 glioma cells (IC50s = 4.7, 2.8, 3.2, and 2.7 µM, respectively)

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6,017

Medchemexpress LLC PRSS3/Trypsin-3 Hum 10ug

Recombinant human PRSS3 (Trypsin-3) is a serine protease that cleaves peptide bonds after arginine residues. This product is supplied as 10 μg of recombinant, polyhistidine-tagged protein intended for enzymatic assays, inhibitor screening, and biochemical characterization.

Recombinant human enzyme for biochemical and enzymatic assays.
Polyhistidine tag facilitates purification and detection.
Supplied in a 10 μg unit size suitable for screening and pilot studies.
Appropriate for activity assays and inhibitor profiling.
Can be aliquoted and stored long term according to manufacturer instructions.

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6,018

Cayman Chemical Bourgeonal, Purity: ≥95%, CAS: 18127-01-0, 25 mg

An hOR17-4 agonist; increases cytosolic calcium levels in human spermatozoa at 5 μM; acts as a chemoattractant and increases swimming speed in sperm chemotaxis assays in a concentration-dependent manner

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6,019

Medchemexpress LLC HY-117930 25mg , Danicopan CAS:1903768-17-1 Purity:>98%

HY-117930 25mg Danicopan CAS: 1903768-17-1 Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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6,020

Cayman Chemical PI-828, Purity: ≥98%, CAS: 942289-87-4, 5 mg

A potent inhibitor of PI3K (IC50s = 9.8, 183, 227, and 1,967 nM for p110β, p110α, p110δ, and p110γ, respectively); has been immobilized on solid surface; interacts with non-PI3K cellular proteins such as mTOR, ALDH1, BRD4, CKIIα, and GSK-3β.

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6,021

TARGETMOL CHEMICALS INC EPIDERMAL GROWTH FACTOR 5MG

Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Epidermal Growth Factor binds to epidermal growth factor receptor (EGFR) and stimulates cell growth and proliferation. It is approved for the treatment of diabetic foot ulcers. purity: 100%

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6,022

Cayman Chemical Cercosporin, Purity: ≥95%, CAS: 35082-49-6, 5 mg

A cytotoxic phytotoxin; produces ROS in plant hosts; has light-activated cytotoxic effects (CC50s = 241, 282, and 174 nM in HeLa, A432, and MCF-7 cells, respectively); a selective inhibitor of PKC (IC50 = 600-1,300 nM) with no activity on PKA or PPK

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6,023

Medchemexpress LLC Hydrazinecarboselenoamide | 21198-79-8 | 95.0% | 50 MG

Selenosemicarbazide, also known as Hydrazinecarboselenoamide, is a chemical compound with the molecular formula CH5N3Se and a molecular weight of 138.03. This off-white to gray solid has a purity of 95.0% by NMR. Derivatives of Selenosemicarbazide have shown indications of antimicrobial activity and potential anti-tumor effects.

Off-white to gray solid
Purity of 95.0%
Potential for antimicrobial activity
Potential for anti-tumor effects (derivatives)
Store powder at -20°C for up to 3 years or 4°C for up to 2 years
Store in solvent at -80°C for up to 6 months or -20°C for up to 1 month

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6,024

Cayman Chemical Cannabipiperidiethanone, Purity: ≥98%, CAS: 1345970-43-5, 5 mg

A synthetic CB that binds to the CB receptors CB1 and CB2 with IC50 values of 591 and 968 nM, respectively; intended for forensic purposes and research applications

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6,025

Cayman Chemical UAMC-3203 (hydrochloride), Purity: ≥98%, CAS: 2271358-65-5, 5 mg

A ferroptosis inhibitor (IC50 = 10 nM for erastin-induced ferroptosis in IMR-32 cells); decreases iron-induced plasma LDH levels in a mouse model of acute iron poisoning at 20 µmol/kg; not toxic to mice at 20 µmol/kg for four weeks

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6,026

Medchemexpress LLC AEBSF hydrochloride | 30827-99-7 | 99.87% | 200 MG

AEBSF hydrochloride is an irreversible inhibitor of serine proteases, including chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. It is for research use only and not sold to patients.

Inhibits the constitutive production of Aβ by directly inhibiting β-secretase in various human cell lines.
Inhibits the lysis of leukemic cells by human macrophages without affecting macrophage secretion of TNF-α and IL-1β.
Disturbs the growth of blastocysts on endometrial cells and inhibits the adhesion of HeLa cells on HUVECs by altering protein secretion.
Prolongs the survival of mice with lethal *T. gondii* infection *in vivo*.
Reduces airway response and inflammation in a cockroach allergen-induced murine model.

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6,027

Cayman Chemical Acolbifene, Purity: ≥98%, CAS: 182167-02-8, 1 mg

A SERM; inhibits E2-induced transcriptional activity of ERα and ERβ (IC50s = 2 and 0.4 nM, respectively); binds to ERs in cytosol from human breast cancer and non-cancerous uterine cells (Kis = 0.047 and 0.042 nM, respectively); binds to ERs in cytosol from rat uterine cells (IC50 = 0.44 nM) but not to progesterone or androgen receptors in cytosol from rat uterine and ventral prostate cells (IC50s = 22,500 and >10,000 nM, respectively); inhibits E2-stimulated proliferation of T47D, ZR-75-1, and MCF-7 breast cancer cells (IC50s = 0.146, 0.75, and 0.321 nM, respectively); inhibits E1-stimulated tumor growth in a ZR-75-1 human breast cancer xenograft model in ovariectomized mice (50 μg per day); inhibits E1-stimulated endometrial epithelium thickening in vivo in ovariectomized mice (50 μg per day)

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6,028

Medchemexpress LLC Irinotecan hydrochloride | 100286-90-6 | 99.9% | 1 ML

Irinotecan hydrochloride is a topoisomerase I inhibitor primarily used to treat colon cancer and rectal cancer. It is intended for research use only.

Acts as a topoisomerase I inhibitor
Inhibits tumor growth in various models
Induces cell cycle arrest and apoptosis
Suitable for in vitro and in vivo studies

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6,029

Medchemexpress LLC Methyl 2-((6S)-4-(4-chlorophenyl)-2-((5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino) | 2243076-67-5 | 98.9% | 50 MG

ZXH-3-26 is a proteolysis targeting chimera (PROTAC) that links a Cereblon ligand to a BRD4 ligand to induce selective BRD4 degradation, with a reported DC50/5h of approximately 5 nM. It is supplied as a 50 mg vial at high purity for use in chemical biology and targeted protein degradation research.

Selective BRD4 degradation with DC50/5h ≈ 5 nM.
Minimal degradation of BRD2 and BRD3 at tested concentrations.
Molecular formula C38H37ClN8O7S and molecular weight 785.27.
Purity 98.9% and supplied as a 50 mg quantity.
Includes SMILES for cheminformatics and structure confirmation.

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6,030

Cayman Chemical MK-0812, Purity: ≥98%, CAS: 624733-88-6, 1 mg

A CCR2 antagonist (IC50 = 5 nM for the human receptor); inhibits mammosphere formation of BT-549 breast cancer cells; increases CCL2 levels and decreases CD11b+ monocytes in mouse blood at 0.03, 0.1, and 0.3 mg/kg

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Bioactive Small Molecules

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Medchemexpress LLC PRSS3/Trypsin-3 Hum 10ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-117930 25mg , Danicopan CAS:1903768-17-1 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Hydrazinecarboselenoamide | 21198-79-8 | 95.0% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC AEBSF hydrochloride | 30827-99-7 | 99.87% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Irinotecan hydrochloride | 100286-90-6 | 99.9% | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Methyl 2-((6S)-4-(4-chlorophenyl)-2-((5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino) | 2243076-67-5 | 98.9% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More